The article analyzes the role of the rule of law and of human rights in relation to the regulation of Artificial Intelligence (AI) and its evolution. The main argument of the article is that the expanding intellectual autonomy of AI at the level of Artificial Narrow Intelligence (ANI), but even more emphatically in the case of Artificial General and Artificial Super Intelligence (AGI and ASI respectively) transforms social relations and the human centric character of present legal systems, both nationally and internationally. [---]