From synthetic biology to artificial intelligence and from blockchain technologies to nanotechnology, a wide range of technological applications are being deployed to combat COVID-19. Are they safe and effective? Have they been tested before in a public health emergency context? Does their use involve risks and threaten our values and rights? This well-timed STOA publication of ten central technological trajectories employed in the fight against this pandemic disease offers us a much-needed analysis of what is at stake in technological terms world-wide, but also of what legislators may need to do in order to tackle the relevant legal and ethical questions.